Modelling of the arteriovenous malformation embolization optimal scenario

Modelling of the arteriovenous malformation embolization optimal scenario Full article

Journal

Royal Society Open Science
ISSN: 2054-5703

Output data

Year: 2020, Volume: 7, Number: 7, Article number : 191992, Pages count : 16 DOI: 10.1098/rsos.191992

Tags

arteriovenous malformation; CABARET scheme; haemodynamics; optimal control; two-phase filtration

Authors

Cherevko Alexandr A. ^1,2 , Gologush Tatiana S. ¹ , Petrenko Irina A. ³ , Ostapenko Vladimir V. ^1,2 , Panarin Vyacheslav A. ⁴

Affiliations

1	Lavrentyev Institute of Hydrodynamics of the Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia
2	Hydrodynamics Department, Novosibirsk State University, 630090 Novosibirsk, Russia
3	Functional Analysis and its Applications Department, Vladimir State University, 600000 Vladimir, Russia
4	Medical Center of Far Eastern Federal University, 690090 Vladivostok, Russia

Funding (2)

1	Российский научный фонд	16-11-10033-Продление
2	Министерство науки и высшего образования Российской Федерации	14.W03.31.0002

Cerebral arteriovenous malformation (AVM) is a congenital brain vessels pathology, in which the arterial and venous blood channels are connected by tangles of abnormal blood vessels. It is a dangerous disease that affects brain functioning causing the high risk of intracerebral haemorrhage. One of AVM treatment methods is embolization - the endovascular filling of the AVM vessel bundle with a special embolic agent. This method is widely used, but still in some cases is accompanied by intraoperative AVM vessels rupture. In this paper, the optimal scenario of AVM embolization is studied from the safety and effectiveness of the procedure point of view. The co-movement of blood and embolic agent in the AVM body is modelled on the basis of a one-dimensional two-phase filtration model. Optimal control problem with phase constraints arising from medicine is formulated and numerically solved. In numerical analysis, the monotone modification of the CABARET scheme is used. Optimal embolization model is constructed on the basis of real patients' clinical data collected during neurosurgical operations. For the special case of embolic agent, input admissible and optimal embolization scenarios were calculated.

Cherevko A.A. , Gologush T.S. , Petrenko I.A. , Ostapenko V.V. , Panarin V.A.
Modelling of the arteriovenous malformation embolization optimal scenario
Royal Society Open Science. 2020. V.7. N7. 191992 :1-16. DOI: 10.1098/rsos.191992 WOS Scopus РИНЦ OpenAlex

Web of science:	WOS:000555028800001
Scopus:	2-s2.0-85090142855
Elibrary:	45326071
OpenAlex:	W3044894338

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Scopus	3
OpenAlex	5
Elibrary	5
Web of science	3