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The Effect of Adding Modified Chitosan on the Strength Properties of Bacterial Cellulose for Clinical Applications Научная публикация

Журнал Polymers
ISSN: 2073-4360
Вых. Данные Год: 2021, Том: 13, Номер: 12, Страницы: 1995 Страниц : 1 DOI: 10.3390/polym13121995
Ключевые слова Bacterial nanocellulose; Chitosan gel; Dura matter; Dura substitutes; Factor analysis; Novochizol™; Tissue biomechanics; Vancomycin
Авторы Lipovka Anna 1 , Kharchenko Alexey 2 , Dubovoy Andrey 1,3 , Filipenko Maxim 4 , Stupak Vyacheslav 2 , Mayorov Alexander 5 , Fomenko Vladislav 6 , Geydt Pavel 7 , Parshin Daniil 1
Организации
1 Lavrentyev Institute of Hydrodynamics of the Siberian Branch of the Russian Academy of Sciences
2 Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya.L. Tsivyan
3 Federal Neurosurgical Center
4 Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences
5 Institute of Laser Physics of the Russian Academy of Sciences
6 N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Russian Academy of Sciences
7 Novosibirsk State University

Информация о финансировании (2)

1 Российский фонд фундаментальных исследований 19-48-540010
2 Министерство науки и высшего образования Российской Федерации 14.W03.31.0002

Реферат: Currently, several materials for the closure of the dura mater (DM) defects are known. However, the long-term results of their usage reveal a number of disadvantages. The use of antibiotics and chitosan is one of the major trends in solving the problems associated with infectious after-operational complications. This work compares the mechanical properties of samples of bacterial nanocellulose (BNC) impregnated with Novochizol ™ and vancomycin with native BNC and preserved and native human DM. An assessment of the possibility of controling the mechanical properties of these materials by changing their thickness has been performed by statistical analysis methods. A total of 80 specimens of comparable samples were investigated. During the analysis, the results obtained, the factor of Novochizol ™ addition has provided a statistically significant impact on the strength properties (Fisher Criteria p-value 0.00509 for stress and 0.00112 for deformation). Moreover, a stronger relationship between the thickness of the samples and their ultimate load was shown: R2 = 0.236 for BNC + Novochizol ™ + vancomycin, compared to R2 = 0.0405 for native BNC. Using factor analysis, it was possible to show a significant effect of modified chitosan (Novochizol ™ ) on the ultimate stress (p-value = 0.005).
Библиографическая ссылка: Lipovka A. , Kharchenko A. , Dubovoy A. , Filipenko M. , Stupak V. , Mayorov A. , Fomenko V. , Geydt P. , Parshin D.
The Effect of Adding Modified Chitosan on the Strength Properties of Bacterial Cellulose for Clinical Applications
Polymers. 2021. V.13. N12. P.1995. DOI: 10.3390/polym13121995 WOS Scopus РИНЦ OpenAlex
Идентификаторы БД:
Web of science: WOS:000666382900001
Scopus: 2-s2.0-85108682491
РИНЦ: 46844349
OpenAlex: W3174765173
Цитирование в БД:
БД Цитирований
Scopus 2
OpenAlex 2
РИНЦ 5
Web of science 2
Альметрики: